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KMID : 1123920120260030293
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.293 ~ p.300
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Anti-inflammatory Effect of Red Ginseng through Regulation of MAPK in Lipopolysaccharide-stimulated RAW264.7
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Shin Ji-Su
Kim Jong-Myoung
An Won-Gun
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Abstract
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Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important inflammatory mediators implicated in pathogenesis of inflammation and certain types of human cancers. The present study was designed to determine whether Red Ginseng (RG) could modulate IκB-kinase, iNOS and COX-2 gene expression and immune responses in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). RG extract suppressed the expression of LPS-induced IκB, iNOS, COX-2, and immune responses in a dose-dependent manner. It also showed an anti-inflammatory effect by inhibiting NF-κB immune response induced by LPS treatment. Inhibitory effect of RG on LPS-induced inflammation was mediated by suppressed phosphorylation of ERK, JNK and p38 through the regulation of the mitogen-activated protein kinase (MAPK) pathway leading to a decreased production of NO, iNOS, COX-2 and NF-κB. The results implied the role of RG as an inflammation regulator and its possible application for curing inflammatory diseases.
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KEYWORD
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Red Ginseng, RAW264.7 macrophages, IκB, NF-κB, iNOS, MAPK, inflammatory diseases
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